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<p>Metal oxide nanoparticles are inexpensive, environmentally benign, and have a low toxicity. These nanoparticles find extensive use in the pharmaceutical and biomedical industries. <i>Barringtonia racemosa</i> (<i>B.racemosa</i>) leaf extract is used in this study to demonstrate the extracellular formation of iron oxide nanoparticles (IONPs) observed through color change after the addition of iron (III) nitrate. UV-vis examination of the nanoparticles revealed a peak at 260 nm associated with the formation of IONPs. Energy dispersive X ray (EDX) measurements verified the iron content of the nanoparticles and revealed their spherical shape by SEM. The size range of spherical nanoparticles, as observed via transmission electron microscopy (TEM), is 86–98 nm. FTIR spectra showed the presence of alcohol, alkene, ketene and aromatic ester groups. Against <i>Staphylococcus epidermidis (S</i>. <i>epidermidis), Methicillin-resistant Staphylococcus aureus (</i>MRSA<i>)</i>, and <i>Pseudomonas aeruginosa (P. aeruginosa)</i>, the IONPs had robust antimicrobial action, with inhibition zones of 40 mm, 35 mm, and 35 mm, respectively. An inhibitory zone of 28 mm was observed against <i>Candida albicans</i>. These nanoparticles were shown to have bactericidal properties when coupled with antibiotics, exhibiting improved inhibitory zones of 43 mm against <i>S. epidermidis</i>, 35 mm against MRSA, and 22 mm against <i>Candida albicans</i>, respectively. Strong antioxidant properties were also shown by these nanoparticles. Thus, to combat microbial resistance in the future, these IONPs may find value in pharmaceutical and biological applications.</p> Graphical Abstract <p></p>

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Ecofriendly synthesis of Iron oxide nanoparticles: a novel tool against Candida albicans and MRSA with antioxidant power

  • 期刊论文

  • 发表日期：

    2025年6月2日

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  • Shahnaz Majeed,
  • Masyitah Binti Zainurin,
  • Mohammed Danish,
  • Abdulaziz M. Alanazi,
  • Afzan Binti Mahmad,
  • Ohoud A. Jefri

摘要

Metal oxide nanoparticles are inexpensive, environmentally benign, and have a low toxicity. These nanoparticles find extensive use in the pharmaceutical and biomedical industries. Barringtonia racemosa (B.racemosa) leaf extract is used in this study to demonstrate the extracellular formation of iron oxide nanoparticles (IONPs) observed through color change after the addition of iron (III) nitrate. UV-vis examination of the nanoparticles revealed a peak at 260 nm associated with the formation of IONPs. Energy dispersive X ray (EDX) measurements verified the iron content of the nanoparticles and revealed their spherical shape by SEM. The size range of spherical nanoparticles, as observed via transmission electron microscopy (TEM), is 86–98 nm. FTIR spectra showed the presence of alcohol, alkene, ketene and aromatic ester groups. Against Staphylococcus epidermidis (S. epidermidis), Methicillin-resistant Staphylococcus aureus (MRSA), and Pseudomonas aeruginosa (P. aeruginosa), the IONPs had robust antimicrobial action, with inhibition zones of 40 mm, 35 mm, and 35 mm, respectively. An inhibitory zone of 28 mm was observed against Candida albicans. These nanoparticles were shown to have bactericidal properties when coupled with antibiotics, exhibiting improved inhibitory zones of 43 mm against S. epidermidis, 35 mm against MRSA, and 22 mm against Candida albicans, respectively. Strong antioxidant properties were also shown by these nanoparticles. Thus, to combat microbial resistance in the future, these IONPs may find value in pharmaceutical and biological applications.

Graphical Abstract