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<p>Technetium-99m is widely used in diagnostic nuclear medicine, but alternative production routes provide low specific activity&#xa0;(LSA) <sup>99</sup>Mo, unsuitable for conventional generators. This study evaluates extraction chromatography resins for the selective separation of <sup>99m</sup>Tc from bulk molybdenum in a reverse generator system. TK202 resin showed high selectivity for pertechnetate in 5&#xa0;M NaOH and negligible molybdenum retention. Column experiments enabled efficient <sup>99m</sup>Tc recovery, mostly within approximately 1&#xa0;mL of water, while <sup>99</sup>Mo was quantitatively recovered for reuse. Repeated separation cycles confirmed stable performance, demonstrating that TK202 resin offers a simple, rapid, and potentially automatable approach for <sup>99m</sup>Tc production from low specific activity <sup>99</sup>Mo.</p>

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Selective separation of Tc-99m from low specific activity Mo-99 in reverse generator system using novel extraction chromatography resins

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月25日

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  • Izabela Cieszykowska,
  • Małgorzata Żółtowska,
  • Kinga Wojciechowska

摘要

Technetium-99m is widely used in diagnostic nuclear medicine, but alternative production routes provide low specific activity (LSA) 99Mo, unsuitable for conventional generators. This study evaluates extraction chromatography resins for the selective separation of 99mTc from bulk molybdenum in a reverse generator system. TK202 resin showed high selectivity for pertechnetate in 5 M NaOH and negligible molybdenum retention. Column experiments enabled efficient 99mTc recovery, mostly within approximately 1 mL of water, while 99Mo was quantitatively recovered for reuse. Repeated separation cycles confirmed stable performance, demonstrating that TK202 resin offers a simple, rapid, and potentially automatable approach for 99mTc production from low specific activity 99Mo.