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<p>The precision and accuracy of a Revvity 6220 GCT Liquid Scintillation Counter (LSC) was tested with a certified tritiated water standard and using a combination of variables including vial type, cocktail selection, and quench curve parameters. Differences in the vial and cocktail choice used for quench measurements and samples were shown to drastically affect the accuracy of the tritium activity measured. Additionally, chemical-based and urine-based quench curves were generated to most closely match the sample matrices analyzed for bioassay samples. Lab generated quench curves designed for programmatic samples performed with improved accuracy compared to commercially available quench standards.</p>

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Improving the accuracy of tritium bioassay measurements through quench curve customization

  • 期刊论文

  • 发表日期：

    2026年3月16日

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  • Raissa N. Chunko,
  • Matthew E. Gooden,
  • Dylan C. Flanagan,
  • Robert E. Steiner,
  • Ralf Sudowe

摘要

The precision and accuracy of a Revvity 6220 GCT Liquid Scintillation Counter (LSC) was tested with a certified tritiated water standard and using a combination of variables including vial type, cocktail selection, and quench curve parameters. Differences in the vial and cocktail choice used for quench measurements and samples were shown to drastically affect the accuracy of the tritium activity measured. Additionally, chemical-based and urine-based quench curves were generated to most closely match the sample matrices analyzed for bioassay samples. Lab generated quench curves designed for programmatic samples performed with improved accuracy compared to commercially available quench standards.