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<p>The secondary neutrons produced during proton therapy could increase the risk of secondary tumors. Due to the lack of nuclear data for neutrons with energies above 20&#xa0;MeV, the accuracy of Monte Carlo simulation still needs to be improved. The secondary neutrons distribution is being studied in this work, combining TOPAS simulation and experimental measurement. The TOPAS simulation results indicate that the neutron ambient dose equivalent at 50&#xa0;cm from the isocenter ranges from 0.19 to 18.6&#xa0;mSv/Gy, whereas measurements using the FHT762 WENDI-2 dosimeter recorded values ranging from 0.96 to 44.21&#xa0;mSv/Gy.</p>

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Study of secondary neutron dose distribution in proton radiotherapy

  • 期刊论文

  • 发表日期：

    2026年2月26日

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  • Wei Cheng,
  • Xiaoqing Sun,
  • Zishen Wang,
  • Shuquan Wei,
  • Gaolong Zhang,
  • Wenbao Jia,
  • Shouping Xu,
  • Dehong Li,
  • Weiwei Qu,
  • Nan Li,
  • Xuying Shang

摘要

The secondary neutrons produced during proton therapy could increase the risk of secondary tumors. Due to the lack of nuclear data for neutrons with energies above 20 MeV, the accuracy of Monte Carlo simulation still needs to be improved. The secondary neutrons distribution is being studied in this work, combining TOPAS simulation and experimental measurement. The TOPAS simulation results indicate that the neutron ambient dose equivalent at 50 cm from the isocenter ranges from 0.19 to 18.6 mSv/Gy, whereas measurements using the FHT762 WENDI-2 dosimeter recorded values ranging from 0.96 to 44.21 mSv/Gy.