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<p>This study investigated the absorbed radiation dose of <sup>113m</sup>In-BBN, targeting gastrin-releasing peptide receptors which are overexpressed in various human cancers. The compound was prepared under optimized conditions, with its radiochemical purity confirmed by RTLC and HPLC. Biodistribution was studied in tumor-bearing mice, and human organ absorbed doses were estimated using mouse data and MIRD method. Results showed the highest absorbed doses in the pancreas and kidneys with the average value of 0.0080 and 0.0034 mGy/MBq, respectively. Based on dosimetric estimates derived from tumor-bearing mice biodistribution data, <sup>113m</sup>In-BBN demonstrated comparatively lower absorbed dose than selected <sup>67</sup>Ga- and <sup>99m</sup>Tc-labeled radiopharmaceuticals.</p>

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Assessment of human organs absorbed dose of 113mIn-BBN: extrapolation from mice biodistribution data using different phantom models

  • 期刊论文

  • 发表日期：

    2026年2月5日

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  • Zahra Saberi,
  • Elham Saeedzadeh,
  • Hassan Yousefnia,
  • Samaneh Zolghadri,
  • Saeed Rajabifar

摘要

This study investigated the absorbed radiation dose of 113mIn-BBN, targeting gastrin-releasing peptide receptors which are overexpressed in various human cancers. The compound was prepared under optimized conditions, with its radiochemical purity confirmed by RTLC and HPLC. Biodistribution was studied in tumor-bearing mice, and human organ absorbed doses were estimated using mouse data and MIRD method. Results showed the highest absorbed doses in the pancreas and kidneys with the average value of 0.0080 and 0.0034 mGy/MBq, respectively. Based on dosimetric estimates derived from tumor-bearing mice biodistribution data, 113mIn-BBN demonstrated comparatively lower absorbed dose than selected 67Ga- and 99mTc-labeled radiopharmaceuticals.