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<p>The depletion of amitraz in sheep is investigated following intramuscular administration of the tritium-labelled [<sup>3</sup>H] drug. A validated liquid scintillation counting (LSC) method was employed to quantify residues in multiple biological matrices from sheep, including blood, urine, milk, feces, and tissues such as kidney, liver, muscle, and fat. Excellent linearity (R<sup>2</sup> ≥ 0.991), low detection limits (2–4 × 10⁻<sup>5</sup>&#xa0;µCi/mL) and very good recovery rates ranging from 72 to 104% were determined. The radioactive drug was distributed rapidly in the sheep, peaking in blood and excreta in a few hours. The amitraz residue levels in edible tissues dropped to trace or undetectable levels by day 28 after treatment. Fat tissue retained the residues the longest, while levels in milk and muscle remained low throughout the experiment. The study findings are relevant for regulatory decisions and responsible use of pesticides such as amitraz for food production.</p>

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Depletion of [3H] amitraz in sheep

  • 期刊论文

  • 发表日期：

    2025年12月24日

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  • Zehra Hajrulai-Musliu,
  • Stefan Jovanovski,
  • Aleksandar Janevski,
  • Dea Musliu,
  • Elizabeta Dimitrieska Stojkovikj,
  • James Jacob Sasanya

摘要

The depletion of amitraz in sheep is investigated following intramuscular administration of the tritium-labelled [3H] drug. A validated liquid scintillation counting (LSC) method was employed to quantify residues in multiple biological matrices from sheep, including blood, urine, milk, feces, and tissues such as kidney, liver, muscle, and fat. Excellent linearity (R2 ≥ 0.991), low detection limits (2–4 × 10⁻5 µCi/mL) and very good recovery rates ranging from 72 to 104% were determined. The radioactive drug was distributed rapidly in the sheep, peaking in blood and excreta in a few hours. The amitraz residue levels in edible tissues dropped to trace or undetectable levels by day 28 after treatment. Fat tissue retained the residues the longest, while levels in milk and muscle remained low throughout the experiment. The study findings are relevant for regulatory decisions and responsible use of pesticides such as amitraz for food production.