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<p>Prostate cancer is the second most common cancer in U.S. men. Current diagnostics, like the Gleason score, have limitations due to tissue heterogeneity and limited molecular insight. This study analyzed trace elements in 142 prostate biopsy samples using INAA and ICP-MS to assess their potential as biomarkers of disease severity. Elements studied included selenium, bromine, magnesium, calcium, zinc, and iron. Most showed expected levels and no significant correlation with Gleason score. However, bromine levels were significantly associated with higher Gleason scores in white patients, suggesting a potential race-dependent biomarker for prostate cancer progression.</p>

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Measurement of trace elements in limited quantity biopsy tissue using INAA and ICP-MS

  • 期刊论文

  • 发表日期：

    2026年1月2日

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  • Michael W. C. Wiles,
  • Ruth-Ann Ngwenyama,
  • Stacy Crane,
  • Li Liu,
  • Soumen Bera,
  • Weiwei Ma,
  • Alan Diamond,
  • John D. Brockman

摘要

Prostate cancer is the second most common cancer in U.S. men. Current diagnostics, like the Gleason score, have limitations due to tissue heterogeneity and limited molecular insight. This study analyzed trace elements in 142 prostate biopsy samples using INAA and ICP-MS to assess their potential as biomarkers of disease severity. Elements studied included selenium, bromine, magnesium, calcium, zinc, and iron. Most showed expected levels and no significant correlation with Gleason score. However, bromine levels were significantly associated with higher Gleason scores in white patients, suggesting a potential race-dependent biomarker for prostate cancer progression.