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<p>Nanoparticle-enhanced radiotherapy holds great promise in improving breast cancer treatment outcomes. This review examines strategies for using nanoparticles, such as gold and silver, as radiosensitizers to enhance radiation therapy while minimizing damage to healthy tissues. Key findings indicate that targeted delivery systems facilitate selective nanoparticle accumulation at tumor sites, increasing therapeutic effects and addressing challenges like radioresistance. The advancements highlighted suggest that nanoparticle technology could lead to more effective, personalized treatment strategies. Future research should focus on optimizing nanoparticle formulations and exploring combination therapies to further boost efficacy.</p> Graphical abstract <p></p>

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Recent developments in nanoparticle-enhanced radiotherapy for breast cancer treatment

  • 期刊论文

  • 发表日期：

    2025年12月12日

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  • Amirreza Khalaji,
  • Alireza Zare,
  • Laith Saheb,
  • S. Renuka Jyothi,
  • Debasish Shit,
  • Bhuvane Swaris,
  • Laxmidhar Maharana,
  • Ahmad Mobed

摘要

Nanoparticle-enhanced radiotherapy holds great promise in improving breast cancer treatment outcomes. This review examines strategies for using nanoparticles, such as gold and silver, as radiosensitizers to enhance radiation therapy while minimizing damage to healthy tissues. Key findings indicate that targeted delivery systems facilitate selective nanoparticle accumulation at tumor sites, increasing therapeutic effects and addressing challenges like radioresistance. The advancements highlighted suggest that nanoparticle technology could lead to more effective, personalized treatment strategies. Future research should focus on optimizing nanoparticle formulations and exploring combination therapies to further boost efficacy.

Graphical abstract