Low energy ion beam induced grafting and crosslinking of IRMOF-3 into guar gum–chitosan hydrogel films for transdermal drug delivery systems
摘要
Biomedical application of controlled drug delivery systems has been evolving over time as these systems, like the hydrogels, require stimulus responsive behaviour depending on the biological environment. Various natural polymer based hydrogels like the polysaccharides are being modified to make them replace the synthetic polymers. Modification of the natural polymers requires incorporation of another functionality or inducing crosslinks or grafting units through methods like irradiation technique, which alters their physiochemical properties to make them biomedically applicable. In this work it was experimentally proven through various characterizations like FTIR, UV etc. where the crosslinked material showed formation of an amide bond at 1700 cm−1 owing to crosslink formation and the grafted material showed shift in the –C–O–C– bond of guar gum from 1140 to 1155 cm−1 and amide bond of chitosan. In case of absorbance spectra, the linking of IRMOF-3 to the polymer matrix either through grafting or crosslinking showed a blue shift and this modification effected not only swelling properties in various pH environment but also effected drug release kinetics. The functionalized irradiated hydrogel film (AT2) fabricated a perfectly crosslinked, biocompatible, controlled pH responsive drug delivery system that showed natural polymers when modified using irradiation are applicable in biomedical field.