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<p>Copper-64(<i>T</i><sub>1/2</sub> = 12.701&#xa0;h) is a useful radioisotope for positron emission tomography (PET). This study explores its efficient preparation process through FLUKA simulation calculations combined with the actual production of a 10&#xa0;MeV low-energy cyclotron. Using <sup>64</sup>Ni as the electroplating raw material to prepare the target, a 30 μA proton beam currents was used to bombard for 4–12&#xa0;h, and <sup>64</sup>Cu was obtained through radiochemical separation with an anion-exchange column. The quality control results show that the production capacity of <sup>64</sup>Cu is 7.92–34.3&#xa0;GBq, the radionuclidic purity is &gt; 99.9%, the radiochemical purity is &gt; 99.0%, and the content of metal impurities is all &lt; 0.1&#xa0;μg/GBq. This preparation process is stable, with controllable quality, reaching the level of large-scale production. It can provide a reference for other medical institutions to prepare new solid-target radionuclides using low-energy medical cyclotron, facilitate the research and development and clinical transformation of <sup>64</sup>Cu-labeled drugs, and bring benefits to cancer patients.</p>

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Production, purification and quality control of 64Cu with 10 MeV medical cyclotron

  • 期刊论文

  • 发表日期：

    2025年12月5日

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  • Yousheng Zhan,
  • Fanhui Yang,
  • Fei Luo,
  • Jun Qin,
  • Yuhui Luo,
  • Suping Li,
  • Bing Tang

摘要

Copper-64(T1/2 = 12.701 h) is a useful radioisotope for positron emission tomography (PET). This study explores its efficient preparation process through FLUKA simulation calculations combined with the actual production of a 10 MeV low-energy cyclotron. Using 64Ni as the electroplating raw material to prepare the target, a 30 μA proton beam currents was used to bombard for 4–12 h, and 64Cu was obtained through radiochemical separation with an anion-exchange column. The quality control results show that the production capacity of 64Cu is 7.92–34.3 GBq, the radionuclidic purity is > 99.9%, the radiochemical purity is > 99.0%, and the content of metal impurities is all < 0.1 μg/GBq. This preparation process is stable, with controllable quality, reaching the level of large-scale production. It can provide a reference for other medical institutions to prepare new solid-target radionuclides using low-energy medical cyclotron, facilitate the research and development and clinical transformation of 64Cu-labeled drugs, and bring benefits to cancer patients.