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<p>The separation of actinium (<sup>228</sup>Ac) from radium (<sup>223,228</sup>Ra) on cation exchange resin with a diethylenetriaminpentaacetic acid-lactate buffer solution is demonstrated with series of columns. High yield, high radiopurity (~ 100%) separations of Ac from Ra are feasible with small columns in biologically compatible conditions and pHs. As Ac is eluted before Ra on these columns, further studies were performed to determine if this separation system could be applied to Ra/Ac isotope generators, but these were not successful. The separations presented in this work may be relevant for radiopharmaceutical purifications of <sup>225</sup>Ac which is typically obtained from its <sup>225</sup>Ra parent isotope.</p>

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Cation exchange separation of radium and actinium using lactic acid DTPA buffer

  • 期刊论文

  • 发表日期：

    2025年11月11日

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  • Kelly N. Kmak,
  • John D. Despotopulos,
  • Tony L. Huynh

摘要

The separation of actinium (228Ac) from radium (223,228Ra) on cation exchange resin with a diethylenetriaminpentaacetic acid-lactate buffer solution is demonstrated with series of columns. High yield, high radiopurity (~ 100%) separations of Ac from Ra are feasible with small columns in biologically compatible conditions and pHs. As Ac is eluted before Ra on these columns, further studies were performed to determine if this separation system could be applied to Ra/Ac isotope generators, but these were not successful. The separations presented in this work may be relevant for radiopharmaceutical purifications of 225Ac which is typically obtained from its 225Ra parent isotope.