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<p>Yttrium-90 (<sup>90</sup>Y), a beta-emitting radionuclide with suitable half-life and radiation energy, is considered an ideal therapeutic nuclide and has been used for the treatment of inflammatory joint diseases, relapsed or refractory B-cell non-Hodgkin's lymphoma, and liver metastases of colorectal cancer. It has great potential for application in nuclear medicine. In this work, stable isotopes were employed to simulate the production conditions of curie-level Y-90 in a system with a Sr/Y concentration ratio of 20,000. The electrolysis was conducted with 0.1&#xa0;M NH<sub>4</sub>NO<sub>3</sub> as the supporting electrolyte, pH adjusted to 2.5, and a current density of 100&#xa0;mA/cm<sup>2</sup> applied for 3&#xa0;h, resulting in a Y recovery rate exceeding 98%. Meanwhile, by adjusting the cathode cleaning step, a theoretical purification factor of (6.8 ± 0.8) × 10<sup>5</sup> was achieved in the simulated secondary electrodeposition. Based on this, a six-step process was developed for the simulated production of 2.4&#xa0;Ci of <sup>90</sup>Y per day and 2.4&#xa0;Ci per week. The obtained Y recovery liquid theoretically conformed to the requirements for medicinal application.</p>

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An optimized two-step electrodeposition procedure for producing 90Y from 90Sr

  • 期刊论文

  • 发表日期：

    2025年10月9日

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  • Mu Ding,
  • Sai Zhou,
  • Yu Chen,
  • Qingyang Wang,
  • Yongdong Jin,
  • Chuanqin Xia

摘要

Yttrium-90 (90Y), a beta-emitting radionuclide with suitable half-life and radiation energy, is considered an ideal therapeutic nuclide and has been used for the treatment of inflammatory joint diseases, relapsed or refractory B-cell non-Hodgkin's lymphoma, and liver metastases of colorectal cancer. It has great potential for application in nuclear medicine. In this work, stable isotopes were employed to simulate the production conditions of curie-level Y-90 in a system with a Sr/Y concentration ratio of 20,000. The electrolysis was conducted with 0.1 M NH4NO3 as the supporting electrolyte, pH adjusted to 2.5, and a current density of 100 mA/cm2 applied for 3 h, resulting in a Y recovery rate exceeding 98%. Meanwhile, by adjusting the cathode cleaning step, a theoretical purification factor of (6.8 ± 0.8) × 105 was achieved in the simulated secondary electrodeposition. Based on this, a six-step process was developed for the simulated production of 2.4 Ci of 90Y per day and 2.4 Ci per week. The obtained Y recovery liquid theoretically conformed to the requirements for medicinal application.