Herein we report proof of principal production of 225Ac via 226Ra(<InlineEquation ID="IEq1"> <EquationSource Format="TEX">$\upgamma$</EquationSource> <EquationSource Format="MATHML"><math> <mi mathvariant="normal">γ</mi> </math></EquationSource> </InlineEquation>, n)225Ra <InlineEquation ID="IEq2"> <EquationSource Format="TEX">$\stackrel{{\upbeta }^{-}}{\to }$</EquationSource> <EquationSource Format="MATHML"><math> <mover> <mo stretchy="false">→</mo> <msup> <mrow> <mi mathvariant="normal">β</mi> </mrow> <mo>-</mo> </msup> </mover> </math></EquationSource> </InlineEquation> 225Ac and subsequent chemical separation via extraction chromatography using BDGA and Ln resins. Irradiation of 0.35 µg 226Ra with 39 MeV bremsstrahlung end-point energy photons produced 225Ra and 224Ra at a rate of 754 and 2215 kBq/g 226Ra/mA/h, respectively. The production rate of 225Ac determined at its peak radioactivity was 335 kBq/g 226Ra/mA/h. Radiochemically pure 225Ac was isolated with a minimum separation factor of 125,000 for 225Ac:226Ra. These results are promising and lay the foundation for future studies to scale-up production for preclinical quantities of high purity 225Ac using the 226Ra(<InlineEquation ID="IEq3"> <EquationSource Format="TEX">$\upgamma$</EquationSource> <EquationSource Format="MATHML"><math> <mi mathvariant="normal">γ</mi> </math></EquationSource> </InlineEquation>, n)225Ra <InlineEquation ID="IEq4"> <EquationSource Format="TEX">$\stackrel{{\upbeta }^{-}}{\to }$</EquationSource> <EquationSource Format="MATHML"><math> <mover> <mo stretchy="false">→</mo> <msup> <mrow> <mi mathvariant="normal">β</mi> </mrow> <mo>-</mo> </msup> </mover> </math></EquationSource> </InlineEquation> 225Ac approach.

Photonuclear production of ²²⁵Ac from ²²⁶Ra targets

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发表日期：

2025年8月21日

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George Diehl,
Thomas V. Holschuh,
Ari Foley-Janish,
Jessica Meiers,
Jacob Brookhart,
Justin Cooper,
Jon Stoner,
Kevin Carney,
Tara Mastren,
Mathew Snow

摘要

Herein we report proof of principal production of ²²⁵Ac via ²²⁶Ra( $\upgamma$ $γ$ , n)²²⁵Ra $\stackrel{{\upbeta }^{-}}{\to }$ $\overset{β^{-}}{\to}$ ²²⁵Ac and subsequent chemical separation via extraction chromatography using BDGA and Ln resins. Irradiation of 0.35 µg ²²⁶Ra with 39 MeV bremsstrahlung end-point energy photons produced ²²⁵Ra and ²²⁴Ra at a rate of 754 and 2215 kBq/g ²²⁶Ra/mA/h, respectively. The production rate of ²²⁵Ac determined at its peak radioactivity was 335 kBq/g ²²⁶Ra/mA/h. Radiochemically pure ²²⁵Ac was isolated with a minimum separation factor of 125,000 for ²²⁵Ac:²²⁶Ra. These results are promising and lay the foundation for future studies to scale-up production for preclinical quantities of high purity ²²⁵Ac using the ²²⁶Ra( $\upgamma$ $γ$ , n)²²⁵Ra $\stackrel{{\upbeta }^{-}}{\to }$ $\overset{β^{-}}{\to}$ ²²⁵Ac approach.

Photonuclear production of 225Ac from 226Ra targets

摘要

Photonuclear production of ²²⁵Ac from ²²⁶Ra targets