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<p>[<sup>64</sup>Cu]Cu-NOTA-JR11 was successfully prepared using a low-energy medical cyclotron and a fully automated solid target purification and synthesis platform. The tracer exhibited excellent radiochemical purity, in vitro stability, and PET imaging properties in preliminary animal studies. The method supports scalable production of <sup>64</sup>Cu-labeled SSTR antagonists and provides a basis for further preclinical development and clinical translation.</p>

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Automated synthesis of [64Cu]Cu-NOTA-JR11 using a solid target medical cyclotron and its preclinical evaluation for SSTR imaging

  • 期刊论文

  • 发表日期：

    2025年8月28日

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  • Fanhui Yang,
  • Yousheng Zhan,
  • Fei Luo,
  • Lingzhi Cao,
  • Fei Chen,
  • Hao Zhang,
  • Suping Li,
  • Hao Xu

摘要

[64Cu]Cu-NOTA-JR11 was successfully prepared using a low-energy medical cyclotron and a fully automated solid target purification and synthesis platform. The tracer exhibited excellent radiochemical purity, in vitro stability, and PET imaging properties in preliminary animal studies. The method supports scalable production of 64Cu-labeled SSTR antagonists and provides a basis for further preclinical development and clinical translation.