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<p>This study successfully synthesized gold-198 nanoparticles ([<sup>198</sup>Au]AuNPs) using <i>Zingiber purpureum</i> rhizome (ZPR) extract as radio-photothermal agents for cancer therapy. The process involved ZPR extract preparation, synthesis of AuNPs, neutron activation, and photothermal evaluation in solution and in vitro. The nanoparticles were spherical, with an average hydrodynamic diameter of 49.1&#xa0;nm as determined by particle size analysis (PSA), exhibited a negative surface charge (− 18.5&#xa0;mV), and showed a radiochemical purity exceeding 99%. Under 532&#xa0;nm laser irradiation (3 W/cm<sup>2</sup>), a 9&#xa0;°C temperature rise was observed. AuNPs-ZPR showed better stability in physiological media compare with AuNPs-Citrate. In vitro photothermal testing using LNCaP cells revealed that 50&#xa0;µg/mL AuNPs-ZPR caused 24% increased cell mortality after 4&#xa0;min of laser exposure. These findings support the application of [<sup>198</sup>Au]AuNPs as promising agents for combined radionuclide and photothermal cancer therapy.</p> Graphical abstract <p></p>

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Synthesis and characterization of [198Au]Au nanoparticles using Zingiber purpureum Roscoe rhizome extract as a potential agent for radio-photothermal therapy

  • 期刊论文

  • 发表日期：

    2025年9月6日

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  • Amal Rezka Putra,
  • Herlan Setiawan,
  • Aulia Arivin Billah,
  • Miftakul Munir,
  • Sumandi Juliyanto,
  • Ahsanal Fikri,
  • Wening Lestari,
  • Veronika Yulianti Susilo,
  • Ligwina Dita Pertiwi,
  • Chaidir Pratama,
  • Dewangga Oky Bagus Apriandanu,
  • Andi Arjuna,
  • Ilma Darojatin,
  • Alfian Mahardika Forentin,
  • Rien Ritawidya,
  • Yoki Yulizar

摘要

This study successfully synthesized gold-198 nanoparticles ([198Au]AuNPs) using Zingiber purpureum rhizome (ZPR) extract as radio-photothermal agents for cancer therapy. The process involved ZPR extract preparation, synthesis of AuNPs, neutron activation, and photothermal evaluation in solution and in vitro. The nanoparticles were spherical, with an average hydrodynamic diameter of 49.1 nm as determined by particle size analysis (PSA), exhibited a negative surface charge (− 18.5 mV), and showed a radiochemical purity exceeding 99%. Under 532 nm laser irradiation (3 W/cm2), a 9 °C temperature rise was observed. AuNPs-ZPR showed better stability in physiological media compare with AuNPs-Citrate. In vitro photothermal testing using LNCaP cells revealed that 50 µg/mL AuNPs-ZPR caused 24% increased cell mortality after 4 min of laser exposure. These findings support the application of [198Au]AuNPs as promising agents for combined radionuclide and photothermal cancer therapy.

Graphical abstract