Scholarlink

<p>This study aimed to radiolabel elmalienoside A, a saponin-based adjuvant, with iodine-131 and evaluate its in vivo biodistribution. [<sup>131</sup>I]iodoelmalienoside A was prepared by the iodogen method and intravenously administered to Balb/C mice. Organ-specific uptake (%ID/g) was assessed at 30, 90, 180, and 1440&#xa0;min post-injection. The radiolabeled compound showed rapid systemic distribution and pronounced accumulation in immune-related organs, especially lymph nodes, spleen, and lungs, indicating strong lymphatic targeting. Renal excretion was dominant. These findings highlight the potential of elmalienoside A as an immunomodulatory radiopharmaceutical for future pharmacokinetic and immunological applications.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Preparation and biodistribution of [131I]iodoelmalienoside a, a saponin-based adjuvant, in mice

  • 期刊论文

  • 发表日期：

    2025年7月15日

查看全文
  • Derya Özel,
  • Nazli Boke Sarikahya,
  • Ayça Tunçel,
  • Ayse Nalbantsoy,
  • Fatma Yurt

摘要

This study aimed to radiolabel elmalienoside A, a saponin-based adjuvant, with iodine-131 and evaluate its in vivo biodistribution. [131I]iodoelmalienoside A was prepared by the iodogen method and intravenously administered to Balb/C mice. Organ-specific uptake (%ID/g) was assessed at 30, 90, 180, and 1440 min post-injection. The radiolabeled compound showed rapid systemic distribution and pronounced accumulation in immune-related organs, especially lymph nodes, spleen, and lungs, indicating strong lymphatic targeting. Renal excretion was dominant. These findings highlight the potential of elmalienoside A as an immunomodulatory radiopharmaceutical for future pharmacokinetic and immunological applications.