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<p>The present study reports the extraction, radiolabeling, and biodistribution of the saponin derivative C1 (3,6-di-O-β-<span>d</span>-xylopyranosyl-3β,6α,16β,24(S),25-penta hydroxycycloartane) labelled with iodine-131. Structural characterization via NMR confirmed successful glycosidation of C1. The radioiodination achieved in high yield of 96.05 ± 1.41%, and biodistribution studies in Albino Wistar rats revealed renal excretion, supported by the compound’s low lipophilicity (log <i>P</i> = − 0.26). These findings suggest that iodine-131-labeled C1 could be a promising candidate for further investigation in nuclear medicine applications. However, given the observed decrease in stability at 240&#xa0;min and the lack of in vivo tumour models or dosimetry studies, its potential for cancer diagnosis and therapy remains to be fully evaluated through additional research.</p>

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Radioiodination of saponin derivative, C1, isolated from Astragalus sp.

  • 期刊论文

  • 发表日期：

    2025年7月15日

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  • Cinel Koksal Karayildirim,
  • Cigdem Ichedef,
  • Ayfer Yurt Kilcar,
  • Fahri Emrah Soylu,
  • Rabia Nur Ün,
  • Tamer Karayildirim,
  • Kübra Topaloglu

摘要

The present study reports the extraction, radiolabeling, and biodistribution of the saponin derivative C1 (3,6-di-O-β-d-xylopyranosyl-3β,6α,16β,24(S),25-penta hydroxycycloartane) labelled with iodine-131. Structural characterization via NMR confirmed successful glycosidation of C1. The radioiodination achieved in high yield of 96.05 ± 1.41%, and biodistribution studies in Albino Wistar rats revealed renal excretion, supported by the compound’s low lipophilicity (log P = − 0.26). These findings suggest that iodine-131-labeled C1 could be a promising candidate for further investigation in nuclear medicine applications. However, given the observed decrease in stability at 240 min and the lack of in vivo tumour models or dosimetry studies, its potential for cancer diagnosis and therapy remains to be fully evaluated through additional research.