Scholarlink

<p>The study evaluated the biological effects of oral radioiodine solution administration in rats, considering DNA damage and apoptosis. Rats were euthanized after treatment and assessed for markers for DNA damage and apoptosis. Results showed no significant variation in γ-H2AX levels in all organs but increased 8-OHdG concentrations in the thyroid and stomach after one day of radioiodine treatment. Caspase-3 levels in the thyroid increased 30&#xa0;min after radioiodine therapy, suggesting a strong positive correlation between γ-H2AX and caspase-3. These findings could inform future research and clinical practice, particularly regarding DNA damage and apoptosis.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The biological effects of oral radioiodine administration on male rats (Rattus norvegicus): DNA damage and apoptosis

  • 期刊论文

  • 发表日期：

    2025年6月27日

查看全文
  • Harry N. E. Surniyantoro,
  • Abinawanto Abinawanto,
  • Teja Kisnanto,
  • Dwi Ramadhani,
  • Indra Saptiama,
  • Iin K. H. Basri,
  • Fadhillah Fadhillah,
  • Retno Lestari,
  • Triningsih Triningsih,
  • Bisma B. Patrianesha,
  • Mukh Syaifudin,
  • Anom Bowolaksono

摘要

The study evaluated the biological effects of oral radioiodine solution administration in rats, considering DNA damage and apoptosis. Rats were euthanized after treatment and assessed for markers for DNA damage and apoptosis. Results showed no significant variation in γ-H2AX levels in all organs but increased 8-OHdG concentrations in the thyroid and stomach after one day of radioiodine treatment. Caspase-3 levels in the thyroid increased 30 min after radioiodine therapy, suggesting a strong positive correlation between γ-H2AX and caspase-3. These findings could inform future research and clinical practice, particularly regarding DNA damage and apoptosis.