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<p>Isotope labeling of α-amino acids is a crucial tool for drug discovery and understanding biochemical processes. The goal for this work was to develop a fast exchange condition to prepare D-[<sup>13</sup>C]phenylalanine in a short time with high incorporation of <sup>13</sup>C isotope, which could be translated to <sup>11</sup>C-α-amino acid. In this work the exchange reactions on preformed imine carboxylate by using [<sup>13</sup>C]CO<sub>2</sub> gave some evidence that the fast exchange to enable direct radiolabeling of α-amino acids, using [<sup>11</sup>C]CO<sub>2,</sub> could be possible.</p>

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12C/13C isotope exchange for the synthesis of D-[13C]phenylalanine by using [13C]CO2 and binol chiral aldehyde receptor

  • 期刊论文

  • 发表日期：

    2025年3月25日

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  • Odey Bsharat

摘要

Isotope labeling of α-amino acids is a crucial tool for drug discovery and understanding biochemical processes. The goal for this work was to develop a fast exchange condition to prepare D-[13C]phenylalanine in a short time with high incorporation of 13C isotope, which could be translated to 11C-α-amino acid. In this work the exchange reactions on preformed imine carboxylate by using [13C]CO2 gave some evidence that the fast exchange to enable direct radiolabeling of α-amino acids, using [11C]CO2, could be possible.