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<p>Tritium labelled radioligands have been extremely useful to advance neurochemistry discovery. In particular, [N-methyl-<sup>3</sup>H] radioligands have been exceptionally valuable in receptor binding and other neurochemical assays because of their very high specific activity. Regarding [N-methyl-<sup>3</sup>H] labelled substances, examination of one of them has revealed its long-term retention of specific activity which is consistent with the phenomenon of tritium decay catastrophe.</p>

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The [N-methyl-3H] group and tritium decay catastrophe

  • 期刊论文

  • 发表日期：

    2025年2月18日

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  • Crist N. Filer

摘要

Tritium labelled radioligands have been extremely useful to advance neurochemistry discovery. In particular, [N-methyl-3H] radioligands have been exceptionally valuable in receptor binding and other neurochemical assays because of their very high specific activity. Regarding [N-methyl-3H] labelled substances, examination of one of them has revealed its long-term retention of specific activity which is consistent with the phenomenon of tritium decay catastrophe.