Investigating the metabolic alterations of metastatic and local prostate cancer patients via PET/CT assisted untargeted metabolomics approach

Prostate cancer is a very common and widespread health problem all over the world. It mostly metastases into bone tissues and pathogenesis become more complicated. In this study, it is aimed to explain etiopathogenesis of local and metastatic prostate cancer via untargeted metabolomics approach. The study was conducted by arranging 36 eligible patients. Their metastasis level were monitored via ⁶⁸Ga-PSMA PET/CT. The large load of tumor cells mostly impacted phenylalanine, tyrosine, thiamin biosynthesis, aminoacyl t-RNA production, and energy metabolism. This PET/CT assisted metabolomics approach may lead to a new perspective on the pathogenesis of high tumour burden on metastasis.