Calculation of the absorbed dose to ^99mTc-HMPAO, ^99mTc-DMSA, and ^99mTc-sulfur colloid injected patients by using Monte Carlo and MIRD methods

This study compares the accuracy of dosimetry calculations using the Monte Carlo (MC) method and the MIRD method for ^99mTc-HMPAO, ^99mTc-DMSA, and ^99mTc-sulfur colloid administered to an adult female patient undergoing SPECT imaging. Comparing the two methods, the dose estimation differences between MC and MIRD methods were found to be 11.57%, 1.70%, and 30.04% for ^99mTc-HMPAO, ^99mTc-DMSA, and ^99mTc-sulfur colloid, respectively. In conclusion, this study emphasizes the importance of accurate dosimetry in nuclear medicine. The MC method perform better than the MIRD method in predicting absorbed doses, making it a valuable tool for optimizing radiation therapies and improving patient outcomes.