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Phytosynthesis of [198Au]Au@SiO2 core–shell nanoparticles for potential radio-photothermal therapy

  • 期刊论文

  • 发表日期：

    2024年5月28日

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  • Ahsanal Fikri,
  • Ligwina Dita Pertiwi,
  • Alfian Mahardika Forentin,
  • Dian Maya Sari,
  • Sumandi Juliyanto,
  • Amal Rezka Putra,
  • Veronika Yulianti Susilo,
  • Muhamad Basit Febrian,
  • Herlan Setiawan,
  • Anung Pujiyanto,
  • Rien Ritawidya,
  • Yoki Yulizar

摘要

[198Au]Au@SiO2 core–shell nanoparticles ([198Au]Au@SiO2 CSNPs) were synthesized using Persea americana Mill. seed (PAS) extract as a reducing agent. The synthesis involves amino-functionalized SiO2 core formation followed by shell formation with [198Au]Au seeds attachment and a reduction process. The resulting [198Au]Au@SiO2 CSNPs, sized at 188.96 nm, exhibited near-infrared (NIR) absorption at 750 nm and radiochemical purity of 99.91%. In vitro treatment, combined with 980 nm laser irradiation at 3 W cm−2, induced hyperthermia, enhancing cell death in LNCaP cancer cells to 2.60% viability. This study highlights the potential of [198Au]Au@SiO2 CSNPs as a promising radio-photothermal therapeutic agent.