The influence of sugar molecule type on the stability of lyophilized human serum albumin (HSA) nanocolloid kit
摘要
Using sugar molecules as lyophilization protectants in HSA nanocolloid kit formulations is critical to obtaining kits with excellent stability. A thermal gelation method with no sugar treatment and variations in sugar (glucose, maltose, and lactose) was applied to produce these kits. The particle size and radiochemical purity results showed that HSA nanocolloid kits with sugar excipients are more stable than those without sugar. The addition of lactose as an excipient (HSA: lactose 1:10) results in a stable nanocolloid system, allowing for the development of novel lyophilized HSA nanocolloid kit formulations.
Graphical abstract