Quantitative comparison between DNA damage RBE of GdNCT and BNCT during brain tumor irradiation

This study aims to quantitatively evaluate the Relative biological effectiveness (RBE) values relevant to two neutron capture therapy (NCT) techniques with Boron and Gadolinium through a hybrid Monte Carlo (MC) simulation. Variations of ¹⁰B and ¹⁵⁷Gd concentration in tumor tissue had a negligible impact on the RBE (RBE_SSB and RBE_DSB) values. The obtained RBE_DSB values for BNCT were remarkably higher than those of GdNCT. On the other hand, RBE_SSB values of GdNCT were greater than the obtained values for BNCT. Hence, BNCT has more strength in tumor cell killing due to the higher RBE_DSB values.