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<p>The work investigated the behavior of a new amphiphilic methacrylic copolymer in mixed monolayers with lipids (lecithin, cholesterol) at their different ratios as potential components of hybrid lipid-polymer nanoparticles. A bottlebrush cationic copolymer with a molecular weight (<i>M</i><sub><i>w</i></sub>) of 69,000 based on oligo(ethylene glycol)methacrylates and 2-(dimethylamino)ethyl methacrylate (DMAEMA) was synthesized using RAFT polymerization. The state of the hybrid lipid-polymer monolayers was governed by the properties of the mixed lecithin-cholesterol monolayers across the studied temperature (24–40&#xa0;°C) and subphase pH (4–8) ranges. The thermoresponsivity of the lipid-polymer monolayers is most pronounced at a lecithin-cholesterol ratio of 3/1 in the lipid component: <i>A</i><sub><i>0</i></sub> increased from 0.8 nm<sup>2</sup>/molec (<i>T</i> = 24&#xa0;°C) to 1.2 nm<sup>2</sup>/molec (<i>T</i> = 36&#xa0;°C). The strongest effect of the subphase pH on the behavior of mixed lipid-polymer monolayers was observed for monolayers in which the lipid phase had a lecithin-cholesterol ratio of 7/1: at pH 4, <i>A</i><sub><i>0</i></sub> reached a maximum value of 1.03 nm<sup>2</sup>/molec and decreased to 0.88 nm<sup>2</sup>/molec at pH 5 and to 0.75 nm<sup>2</sup>/molec at pH 8. The effect of lipids initially deposited on the water-air interface on the properties of mixed lipid-polymer monolayers was manifested in an increase in the compressibility modulus of the copolymer from 35 mN/m to 46–59 mN/m over the entire studied pH and temperature range. Thus, the mild effect of temperature and pH on the self-assembly of the DMAEMA-containing cationic copolymer in mixed lipid-polymer monolayers may be a prerequisite for obtaining hybrid lipid-polymer nanoparticles for targeted delivery of drugs.</p> Graphical Abstract <p></p>

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Bottlebrush methacrylic amphiphilic copolymer as potential component of hybrid lipid-polymer lipoplexes based on the colloidal-chemical approach of their behavior in Langmuir monolayers

  • 期刊论文

  • 发表日期：

    2026年7月30日

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  • Olga Zamyshlyayeva,
  • Ekaterina Kurbatova,
  • Alexey Sivokhin,
  • Oleg Kazantsev,
  • Ilya Chuzhaykin,
  • Alexey Belikov

摘要

The work investigated the behavior of a new amphiphilic methacrylic copolymer in mixed monolayers with lipids (lecithin, cholesterol) at their different ratios as potential components of hybrid lipid-polymer nanoparticles. A bottlebrush cationic copolymer with a molecular weight (Mw) of 69,000 based on oligo(ethylene glycol)methacrylates and 2-(dimethylamino)ethyl methacrylate (DMAEMA) was synthesized using RAFT polymerization. The state of the hybrid lipid-polymer monolayers was governed by the properties of the mixed lecithin-cholesterol monolayers across the studied temperature (24–40 °C) and subphase pH (4–8) ranges. The thermoresponsivity of the lipid-polymer monolayers is most pronounced at a lecithin-cholesterol ratio of 3/1 in the lipid component: A0 increased from 0.8 nm2/molec (T = 24 °C) to 1.2 nm2/molec (T = 36 °C). The strongest effect of the subphase pH on the behavior of mixed lipid-polymer monolayers was observed for monolayers in which the lipid phase had a lecithin-cholesterol ratio of 7/1: at pH 4, A0 reached a maximum value of 1.03 nm2/molec and decreased to 0.88 nm2/molec at pH 5 and to 0.75 nm2/molec at pH 8. The effect of lipids initially deposited on the water-air interface on the properties of mixed lipid-polymer monolayers was manifested in an increase in the compressibility modulus of the copolymer from 35 mN/m to 46–59 mN/m over the entire studied pH and temperature range. Thus, the mild effect of temperature and pH on the self-assembly of the DMAEMA-containing cationic copolymer in mixed lipid-polymer monolayers may be a prerequisite for obtaining hybrid lipid-polymer nanoparticles for targeted delivery of drugs.

Graphical Abstract