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<p>Bacterial Cellulose (BC) and Collagen (COL) serve as fundamental scaffolds in tissue engineering for their structural similarity to the extracellular matrix, while hyaluronic acid (HA), as a biological regulator, enhances wound repair. In this study, BC membrane was incorporated with HA and COL at a specific volumetric ratio of 5:1:1 (BC/COL/HA) for fabrication a new composite membrane for its potential in accelerating wound-healing enhancement. Production of BC by <i>Acetobacter indonesiensis</i> PV549390 was optimized via static fermentation using response surface approach, while collagen was sustainably sourced from sea bass scales. Systematic characterization confirmed successful polymer integration, revealing a uniform morphology and enhanced thermal stability. Furthermore, both in vitro and in vivo studies demonstrated the fabricated BC/COL/HA membrane exhibited a superior biological performance and therapeutic efficacy in accelerating wound closure. The biocompatibility of BC/COL/HA membrane was quantitatively assessed using human skin fibroblasts, resulting in an IC<sub>50</sub> value of 747.25&#xa0;µg/mL, confirming the safety in cellular environments. The treated wounds with BC/COL/HA membrane revealed complete re-epithelialization, dense collagen deposition, and minimal inflammatory response. By successfully merging the mechanical robustness of bacterial cellulose with the biological activity of collagen and hyaluronic acid in mediating cellular regeneration and moisture retention, this study presents a sustainable, biocompatible wound dressing with significant clinical promise. Unlike reported binary systems, this biomimetic ternary composite provides superior structural integration, providing a sustainable and scalable strategy for the fabrication of functional biomaterials with significant potential in regenerative medicine and broad relevance to the polymer science community.</p>

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Improving wound dressing applications of the fabricated bacterial cellulose membrane incorporated hyaluronic acid and marine collagen

  • 期刊论文

  • 发表日期：

    2026年7月22日

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  • Hanaa Orabi,
  • Manal Shalaby,
  • Ebtesam Naeim Hussieny,
  • Monira Zhran,
  • Yousra A. El-Maradny,
  • Esmail M. El-Fkharany

摘要

Bacterial Cellulose (BC) and Collagen (COL) serve as fundamental scaffolds in tissue engineering for their structural similarity to the extracellular matrix, while hyaluronic acid (HA), as a biological regulator, enhances wound repair. In this study, BC membrane was incorporated with HA and COL at a specific volumetric ratio of 5:1:1 (BC/COL/HA) for fabrication a new composite membrane for its potential in accelerating wound-healing enhancement. Production of BC by Acetobacter indonesiensis PV549390 was optimized via static fermentation using response surface approach, while collagen was sustainably sourced from sea bass scales. Systematic characterization confirmed successful polymer integration, revealing a uniform morphology and enhanced thermal stability. Furthermore, both in vitro and in vivo studies demonstrated the fabricated BC/COL/HA membrane exhibited a superior biological performance and therapeutic efficacy in accelerating wound closure. The biocompatibility of BC/COL/HA membrane was quantitatively assessed using human skin fibroblasts, resulting in an IC50 value of 747.25 µg/mL, confirming the safety in cellular environments. The treated wounds with BC/COL/HA membrane revealed complete re-epithelialization, dense collagen deposition, and minimal inflammatory response. By successfully merging the mechanical robustness of bacterial cellulose with the biological activity of collagen and hyaluronic acid in mediating cellular regeneration and moisture retention, this study presents a sustainable, biocompatible wound dressing with significant clinical promise. Unlike reported binary systems, this biomimetic ternary composite provides superior structural integration, providing a sustainable and scalable strategy for the fabrication of functional biomaterials with significant potential in regenerative medicine and broad relevance to the polymer science community.