Scholarlink

<p>This study reports the development of multifunctional bacterial cellulose/chitosan (BC/CS) composite films incorporated with <i>Piper betle</i> leaf extract (PBLE) as sustainable bioactive platforms for pharmaceutical preservation and active packaging applications. The incorporation of PBLE generated mechanically reinforced, UV-protective, antibacterial, and release-regulated films through synergistic interactions between the nanofibrillar BC network, cationic chitosan matrix, and phenolic-rich phytochemicals. The optimized BC/CS–PBLE film exhibited enhanced tensile strength (61.8 ± 2.9&#xa0;MPa), strong UV-shielding capability with UV transmittance reduced to 8.9 ± 0.8% at 280&#xa0;nm, and pronounced antibacterial activity against <i>Staphylococcus aureus</i>. LC–MS/MS analysis identified hydroxychavicol, eugenol, and catechin as the principal retained bioactive compounds within the composite matrix. Release studies demonstrated clear pH-responsive behavior, with cumulative PBLE release reaching approximately 73%, 84%, and 93% at pH 5, 7, and 9 after 96&#xa0;h, respectively. Kinetic modeling revealed that the First-order model provided strong predictive performance, while the Korsmeyer–Peppas model indicated coupled diffusion–relaxation-controlled transport within the hydrated BC/CS network. In addition, the composite films showed improved photostability and significantly enhanced retention of bioactive compounds during storage, confirming the protective role of the BC/CS matrix against oxidative and UV-induced degradation. Compared with previously reported BC/chitosan-based active films that mainly focused on antibacterial or antioxidant functions alone, the present system integrates phytochemical characterization, pH-responsive release kinetics, UV shielding, photostability, and sustained bioactive stabilization within a single multifunctional platform. Importantly, the developed films provide practical potential for pharmaceutical preservation, antimicrobial protective coatings, and active packaging systems requiring sustained bioactive availability, UV shielding, and prolonged functional stability. More broadly, this work establishes a structure–composition–function relationship linking phytochemical retention, polymer-network interactions, and controlled-release behavior in multifunctional BC/chitosan systems. The findings help bridge the gap between phytochemical-guided bioactive engineering and sustainable polymer design, while providing broader insights for the development of next-generation biopolymer composites with integrated antimicrobial, UV-protective, and tunable delivery functions for advanced pharmaceutical and packaging applications. This strategy may also be extended to other phytochemical-loaded biopolymer systems for sustainable biomedical and packaging technologies.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Engineering multifunctional bacterial cellulose/chitosan nanocomposite films integrated with Piper betle leaf extract for enhanced mechanical strength, UV shielding, and controlled bioactive release

  • 期刊论文

  • 发表日期：

    2026年5月29日

查看全文
  • Tuan Anh Nguyen,
  • Ngoc Thanh Nguyen,
  • Huu Trung Dang

摘要

This study reports the development of multifunctional bacterial cellulose/chitosan (BC/CS) composite films incorporated with Piper betle leaf extract (PBLE) as sustainable bioactive platforms for pharmaceutical preservation and active packaging applications. The incorporation of PBLE generated mechanically reinforced, UV-protective, antibacterial, and release-regulated films through synergistic interactions between the nanofibrillar BC network, cationic chitosan matrix, and phenolic-rich phytochemicals. The optimized BC/CS–PBLE film exhibited enhanced tensile strength (61.8 ± 2.9 MPa), strong UV-shielding capability with UV transmittance reduced to 8.9 ± 0.8% at 280 nm, and pronounced antibacterial activity against Staphylococcus aureus. LC–MS/MS analysis identified hydroxychavicol, eugenol, and catechin as the principal retained bioactive compounds within the composite matrix. Release studies demonstrated clear pH-responsive behavior, with cumulative PBLE release reaching approximately 73%, 84%, and 93% at pH 5, 7, and 9 after 96 h, respectively. Kinetic modeling revealed that the First-order model provided strong predictive performance, while the Korsmeyer–Peppas model indicated coupled diffusion–relaxation-controlled transport within the hydrated BC/CS network. In addition, the composite films showed improved photostability and significantly enhanced retention of bioactive compounds during storage, confirming the protective role of the BC/CS matrix against oxidative and UV-induced degradation. Compared with previously reported BC/chitosan-based active films that mainly focused on antibacterial or antioxidant functions alone, the present system integrates phytochemical characterization, pH-responsive release kinetics, UV shielding, photostability, and sustained bioactive stabilization within a single multifunctional platform. Importantly, the developed films provide practical potential for pharmaceutical preservation, antimicrobial protective coatings, and active packaging systems requiring sustained bioactive availability, UV shielding, and prolonged functional stability. More broadly, this work establishes a structure–composition–function relationship linking phytochemical retention, polymer-network interactions, and controlled-release behavior in multifunctional BC/chitosan systems. The findings help bridge the gap between phytochemical-guided bioactive engineering and sustainable polymer design, while providing broader insights for the development of next-generation biopolymer composites with integrated antimicrobial, UV-protective, and tunable delivery functions for advanced pharmaceutical and packaging applications. This strategy may also be extended to other phytochemical-loaded biopolymer systems for sustainable biomedical and packaging technologies.