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<p>Due to their ability to accelerate cell proliferation and their close resemblance to the native extracellular matrix (ECM) of skin, electrospun nanofibers have gained increasing attention in wound healing research. In this study, electrospun silk fibroin/polyethylene oxide (SF/PEO) nanofibrous dressings incorporating honey and silver nanoparticles were successfully developed and compared with control samples lacking honey and silver nanoparticles. Uniform, bead-free nanofibers with nanoscale diameters were fabricated using the electrospinning technique. Among the investigated formulations, the SF-P-H10-Ag nanofibers exhibited superior overall performance compared with SF-P-H15-Ag. Specifically, the SF-P-H10-Ag nanofibers showed approximately 30% smaller fiber diameter, resulting in increased surface area and porosity, which led to enhanced water absorption (~ 13%) and higher water vapor permeability (~ 18%). Furthermore, this formulation demonstrated improved stability, including a 15% slower degradation rate over 14 days and a more controlled release of silver nanoparticles (~ 15% lower after 7 days). Biological evaluations revealed that SF-P-H10-Ag nanofibers supported higher fibroblast viability (~ 5%) and exhibited excellent antibacterial activity against both <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i>. Additionally, their mechanical properties were comparable to those of native human skin. Overall, these findings demonstrate the synergistic effect of silk fibroin/PEO, honey, and silver nanoparticles within an optimized electrospun nanofibrous structure and identify SF-P-H10-Ag as a promising candidate for advanced wound dressing systems.</p>

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Electrospun silk fibroin–PEO composite nanofibers loaded with honey and silver nanoparticles: a pharmaceutical model study​

  • 期刊论文

  • 发表日期：

    2026年4月23日

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  • Hadis Aboheidari,
  • Maryam Tajabadi,
  • Hajar Ghanbari,
  • Jebrail Movaffagh

摘要

Due to their ability to accelerate cell proliferation and their close resemblance to the native extracellular matrix (ECM) of skin, electrospun nanofibers have gained increasing attention in wound healing research. In this study, electrospun silk fibroin/polyethylene oxide (SF/PEO) nanofibrous dressings incorporating honey and silver nanoparticles were successfully developed and compared with control samples lacking honey and silver nanoparticles. Uniform, bead-free nanofibers with nanoscale diameters were fabricated using the electrospinning technique. Among the investigated formulations, the SF-P-H10-Ag nanofibers exhibited superior overall performance compared with SF-P-H15-Ag. Specifically, the SF-P-H10-Ag nanofibers showed approximately 30% smaller fiber diameter, resulting in increased surface area and porosity, which led to enhanced water absorption (~ 13%) and higher water vapor permeability (~ 18%). Furthermore, this formulation demonstrated improved stability, including a 15% slower degradation rate over 14 days and a more controlled release of silver nanoparticles (~ 15% lower after 7 days). Biological evaluations revealed that SF-P-H10-Ag nanofibers supported higher fibroblast viability (~ 5%) and exhibited excellent antibacterial activity against both Staphylococcus aureus and Pseudomonas aeruginosa. Additionally, their mechanical properties were comparable to those of native human skin. Overall, these findings demonstrate the synergistic effect of silk fibroin/PEO, honey, and silver nanoparticles within an optimized electrospun nanofibrous structure and identify SF-P-H10-Ag as a promising candidate for advanced wound dressing systems.