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<p>Acid hydrolysis is a well-established approach for modifying the physicochemical properties of polysaccharides, including hydroxypropyl methylcellulose (HPMC). In this study, the effect of varying concentrations of hydrochloric acid on the partial hydrolytic degradation of HPMC (Anycoat-c AN4 grade) was investigated at 80&#xa0;°C for 3&#xa0;h, yielding polymers of different molecular weights. The impact of acid-mediated degradation on polymer characteristics was systematically examined using capillary viscometry and size exclusion chromatography (SEC) to determine molecular weight and distribution. Films prepared from the degraded polymers were further evaluated for glass transition temperature, tensile strength, and thermal stability. Additionally, paracetamol-loaded HPMC microspheres were fabricated from the hydrolyzed polymer solutions to assess the influence of degradation on drug release behavior. Dissolution studies revealed that hydrolytic degradation markedly altered the release kinetics (i.e. improvement in drug dissolution from 45 to 16&#xa0;min in bile solution), demonstrating that acid hydrolysis is a practical and effective strategy to fine-tune the drug release characteristics of HPMC-coated microspheres.</p>

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Tailoring the molecular weights of the pharmaceutical cellulose using facile hydrolysis to improve the solubility characteristics of micro-pellets

  • 期刊论文

  • 发表日期：

    2026年4月9日

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  • Ajay Giripunje,
  • Srikanth Bhaskar Billa,
  • Someshwarnath Pandey,
  • Vishnudev Gupta,
  • Bishwabhusana Palai

摘要

Acid hydrolysis is a well-established approach for modifying the physicochemical properties of polysaccharides, including hydroxypropyl methylcellulose (HPMC). In this study, the effect of varying concentrations of hydrochloric acid on the partial hydrolytic degradation of HPMC (Anycoat-c AN4 grade) was investigated at 80 °C for 3 h, yielding polymers of different molecular weights. The impact of acid-mediated degradation on polymer characteristics was systematically examined using capillary viscometry and size exclusion chromatography (SEC) to determine molecular weight and distribution. Films prepared from the degraded polymers were further evaluated for glass transition temperature, tensile strength, and thermal stability. Additionally, paracetamol-loaded HPMC microspheres were fabricated from the hydrolyzed polymer solutions to assess the influence of degradation on drug release behavior. Dissolution studies revealed that hydrolytic degradation markedly altered the release kinetics (i.e. improvement in drug dissolution from 45 to 16 min in bile solution), demonstrating that acid hydrolysis is a practical and effective strategy to fine-tune the drug release characteristics of HPMC-coated microspheres.