Scholarlink

<p>Coaxial electrospinning was employed to prepare hybrid nanofibers integrating micelles of chitosan grafted with oleic acid (CS-<i>g</i>-OA) within a poly(vinyl alcohol) (PVA) core. The micellar system was encapsulated by a composite shell of sodium polyaspartate (PAsp), gellan gum (GG), carboxymethyl chitosan (cMCS), and PVA. Coumarin-6 (C6) was used as a model fluorescent probe to evaluate micelle encapsulation and distribution within the coaxial structure. The resulting fibers exhibited a uniform morphology with average shell diameters of 170&#xa0;nm and 222&#xa0;nm, respectively. CS-<i>g</i>-OA micelles displayed a hydrodynamic diameter of 335&#xa0;nm and achieved a 30% encapsulation efficiency of C6, which increased to 66% after incorporation into the coaxial fiber. This enhancement demonstrates effective retention of the hydrophobic probe through micelle entrapment within the polymeric matrix. The composite system combines biodegradability, biocompatibility, and fluorescence traceability, offering a promising platform for localized delivery and visualization of hydrophobic therapeutics.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Coaxially electrospun fibers incorporating chitosan-graft-oleic acid micelles for the fluorescent tracking of coumarin-6

  • 期刊论文

  • 发表日期：

    2026年3月23日

查看全文
  • Carmen Luz Zegarra-Urquia,
  • Erasto Armando Zaragoza-Contreras

摘要

Coaxial electrospinning was employed to prepare hybrid nanofibers integrating micelles of chitosan grafted with oleic acid (CS-g-OA) within a poly(vinyl alcohol) (PVA) core. The micellar system was encapsulated by a composite shell of sodium polyaspartate (PAsp), gellan gum (GG), carboxymethyl chitosan (cMCS), and PVA. Coumarin-6 (C6) was used as a model fluorescent probe to evaluate micelle encapsulation and distribution within the coaxial structure. The resulting fibers exhibited a uniform morphology with average shell diameters of 170 nm and 222 nm, respectively. CS-g-OA micelles displayed a hydrodynamic diameter of 335 nm and achieved a 30% encapsulation efficiency of C6, which increased to 66% after incorporation into the coaxial fiber. This enhancement demonstrates effective retention of the hydrophobic probe through micelle entrapment within the polymeric matrix. The composite system combines biodegradability, biocompatibility, and fluorescence traceability, offering a promising platform for localized delivery and visualization of hydrophobic therapeutics.

Graphical Abstract