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<p><i>Camellia sinensis</i> extract from green tea leaves (GT) has been well-documented in the literature for its numerous health benefits, including remarkable antioxidant activity, which is believed to effectively neutralize excessive reactive oxygen species (ROS), especially during the inflammatory phase of wound healing. Herein, this study investigates the physicochemical aspects of herbal antioxidant-loaded dissolving microneedle patches by incorporating GT within a poly(vinyl alcohol)/polyvinylpyrrolidone (PVA/PVP) matrix for potential wound dressing applications using the micromolding technique. Physicochemical characterization of the PVA/PVP@GT microneedle patches, including morphological, chemical, thermal stability, mechanical, penetration, dissolution, and antioxidant properties, was comprehensively evaluated. Experimental results from this work demonstrated that the obtained microneedles exhibited well-formed morphological structures, successful loading of the materials with high thermal stability, sufficient mechanical strength, effective skin penetration, and rapid dissolution within 5–10&#xa0;min. Notably, the DPPH radical scavenging assay revealed that the proposed system has shown significant antioxidant activity. These findings highlight the potential for future biological and clinical translational research of this simple, low-cost, and patient-friendly microneedle-based delivery system for delivering herbal-loaded antioxidants to accelerate wound healing.</p>

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Camellia sinensis extract-loaded PVA/PVP dissolving microneedle patches for potential herbal-derived antioxidant dressings: fabrication and physicochemical investigations

  • 期刊论文

  • 发表日期：

    2026年3月19日

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  • Tien Dat Nguyen,
  • Thi-Hiep Nguyen,
  • Thanh-Qua Nguyen

摘要

Camellia sinensis extract from green tea leaves (GT) has been well-documented in the literature for its numerous health benefits, including remarkable antioxidant activity, which is believed to effectively neutralize excessive reactive oxygen species (ROS), especially during the inflammatory phase of wound healing. Herein, this study investigates the physicochemical aspects of herbal antioxidant-loaded dissolving microneedle patches by incorporating GT within a poly(vinyl alcohol)/polyvinylpyrrolidone (PVA/PVP) matrix for potential wound dressing applications using the micromolding technique. Physicochemical characterization of the PVA/PVP@GT microneedle patches, including morphological, chemical, thermal stability, mechanical, penetration, dissolution, and antioxidant properties, was comprehensively evaluated. Experimental results from this work demonstrated that the obtained microneedles exhibited well-formed morphological structures, successful loading of the materials with high thermal stability, sufficient mechanical strength, effective skin penetration, and rapid dissolution within 5–10 min. Notably, the DPPH radical scavenging assay revealed that the proposed system has shown significant antioxidant activity. These findings highlight the potential for future biological and clinical translational research of this simple, low-cost, and patient-friendly microneedle-based delivery system for delivering herbal-loaded antioxidants to accelerate wound healing.