Scholarlink

<p>The research aims to develop a pH-sensitive hydrogel using <i>Ocimum Basilicum</i> seed mucilage and mucin for colon targeting. Free radical polymerization (FRP) was tailored to create hydrogels using methacrylic acid (MAA) as a monomer and <i>Ocimum Basilicum</i> mucilage and mucin as polymers. FTIR spectra confirmed the presence of cross-linking in the developed co-polymeric hydrogel. DSC findings revealed the thermal profile of the hydrogel. The formulated hydrogel appeared porous in SEM photomicrographs. Volume transition and dissolution studies were carried out at multiple pH levels to assess and validate the pH-responsive properties of the hydrogel. At pH 7.4, substantial expansion and discharge were found in contrast to pH 1.2. Gastric pH limits acyclovir release into the stomach due to decreased swelling, whereas it significantly increases swelling and releases acyclovir into the colon. Acute oral toxicity investigations were performed to measure the safety and biocompatibility of hydrogels, and the results affirm the biocompatibility of fabricated hydrogels. These findings demonstrated that the developed hydrogel network is capable of delivering acyclovir to the colonic segment of the gastrointestinal tract for an extended time.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Development and characterization of smart hydrogel scaffolds of Ocimum basilicum seed mucilage for controlled delivery of acyclovir

  • 期刊论文

  • 发表日期：

    2026年4月26日

查看全文
  • Nazia Koser,
  • Muhammad Umer Ashraf,
  • Muhammad Sarfraz,
  • Asif Mahmood,
  • Hira Ijaz,
  • Rai Muhammad Sarfraz,
  • Javed Iqbal,
  • Areej Alsubaie,
  • Ehab I. Taha,
  • Mounir M. Bekhit

摘要

The research aims to develop a pH-sensitive hydrogel using Ocimum Basilicum seed mucilage and mucin for colon targeting. Free radical polymerization (FRP) was tailored to create hydrogels using methacrylic acid (MAA) as a monomer and Ocimum Basilicum mucilage and mucin as polymers. FTIR spectra confirmed the presence of cross-linking in the developed co-polymeric hydrogel. DSC findings revealed the thermal profile of the hydrogel. The formulated hydrogel appeared porous in SEM photomicrographs. Volume transition and dissolution studies were carried out at multiple pH levels to assess and validate the pH-responsive properties of the hydrogel. At pH 7.4, substantial expansion and discharge were found in contrast to pH 1.2. Gastric pH limits acyclovir release into the stomach due to decreased swelling, whereas it significantly increases swelling and releases acyclovir into the colon. Acute oral toxicity investigations were performed to measure the safety and biocompatibility of hydrogels, and the results affirm the biocompatibility of fabricated hydrogels. These findings demonstrated that the developed hydrogel network is capable of delivering acyclovir to the colonic segment of the gastrointestinal tract for an extended time.