<p>Pharmaceutical residues in water sources pose serious environmental and health risks due to their persistence and potential to induce antibiotic resistance. In this study, a novel photocatalytic composite film comprising few-layer molybdenum disulfide (MoS₂) single crystals embedded in a cellulose acetate (CA) matrix was synthesized for the efficient photodegradation of commonly used antibiotic tablets, Amoxicillin and Cefixime. The MoS₂ nanosheets were exfoliated and uniformly dispersed within the CA polymer through a simple solution-casting method. Structural and morphological characterizations confirmed the successful incorporation of MoS₂ into the polymer matrix, forming a stable and flexible composite film. Under visible light irradiation, the MoS₂/CA film exhibited notable photocatalytic performance, achieving degradation efficiencies of 84.31% for Amoxicillin and 76.11% for Cefixime within a specific reaction time. The enhanced degradation activity is attributed to the high surface area of few-layer MoS₂, which facilitates effective light absorption and reactive oxygen species generation, while the CA matrix provides a biodegradable and environmentally friendly support. This work demonstrates the potential of MoS₂-based biopolymer composites as sustainable photocatalysts for removing pharmaceutical contaminants from aqueous environments. The results offer a promising route for designing efficient and green photocatalytic systems to address emerging water pollution challenges.</p> Graphical Abstract <p></p>