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<p>Modification in the starch from micro to nanoscale plays an important role to enhance its functional properties and its application. Nowadays, starch nanoparticles are used as a sustainable alternative to common nanomaterials in healthcare due to its remarkable properties like biocompatibility, non-toxicity, and biodegradability. In the present study, starch nanoparticles are synthesized by physical, chemical, and biological methods. Raw starch of <i>Fagopyrum esculentum</i> were treated with gamma radiation, UV-radiation, ultrasonication, and enzymolysis method to obtained starch nanoparticles (StNPs). These nanoparticles were characterized using FESEM, DLS, FTIR, and XRD. Among all, average size (193&#xa0;nm) and surface area (1.86 m<sup>2</sup>/g) of StNPs prepared from enzymolysis is significantly larger than physical method StNPs. Therefore, theses nanoparticles are used for drug delivery of curcumin (CUR) to MCF-7 cell-lines. In case of CUR loaded StNPs, cell viability is affected about 51% and in presence of StNPs 40%. Both StNPs and CUR loaded StNPs are observed as a good antimicrobial agent. MIC values of StNPs and CUR loaded StNPs values are 60&#xa0;µg/ml and 20&#xa0;µg/ml respectively.</p> Graphical abstract <p></p>

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Synthesis of curcumin loaded starch nanoparticles: characterizations and application

  • 期刊论文

  • 发表日期：

    2025年12月26日

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  • Aparna Dhavade,
  • Sarika Hinge,
  • Sushma Sabharwal

摘要

Modification in the starch from micro to nanoscale plays an important role to enhance its functional properties and its application. Nowadays, starch nanoparticles are used as a sustainable alternative to common nanomaterials in healthcare due to its remarkable properties like biocompatibility, non-toxicity, and biodegradability. In the present study, starch nanoparticles are synthesized by physical, chemical, and biological methods. Raw starch of Fagopyrum esculentum were treated with gamma radiation, UV-radiation, ultrasonication, and enzymolysis method to obtained starch nanoparticles (StNPs). These nanoparticles were characterized using FESEM, DLS, FTIR, and XRD. Among all, average size (193 nm) and surface area (1.86 m2/g) of StNPs prepared from enzymolysis is significantly larger than physical method StNPs. Therefore, theses nanoparticles are used for drug delivery of curcumin (CUR) to MCF-7 cell-lines. In case of CUR loaded StNPs, cell viability is affected about 51% and in presence of StNPs 40%. Both StNPs and CUR loaded StNPs are observed as a good antimicrobial agent. MIC values of StNPs and CUR loaded StNPs values are 60 µg/ml and 20 µg/ml respectively.

Graphical abstract