<p>This study was to investigate water-soluble plastic films designated for storing infected clothes in hospitalized patients. Blends of polyvinyl alcohol (PVA), pregelatinized starch (P-St), poly(ethylene glycol) (PEG) and glycerol were processed via blown film extrusion to examine the impact of PEG and glycerol ratios (1:1, 2:1, and 3:1) on water solubility, mechanical properties, thermal properties, and morphological characteristics. Considering the melt flow index (MFI), glycerol could enhance chain mobility and acted as an interior plasticizer. While PEG reduced MFI due to better polymer interactions acting as an external plasticizer. FT-IR analysis revealed that PVA/P-St incorporated with PEG-rich blends had shown more hydrogen bonding than the one with glycerol-rich blends. Thermally, it revealed multi-stage degradation, confirming strong component interactions. DSC demonstrated PEG of lowering glass transition temperature (T_g) and enhancing flexibility. While the increment of PEG unexpectedly raised T_g, indicating phase separation. Crystallinity and melting points decreased with more PEG amounts which highlighted complicated plasticization effects. These findings pave the way to the designs of biodegradable polymer blends. Mechanically, blends with higher PEG content showed relatively higher tensile strength and elongation at break than the ones with lower PEG content due to higher molecular weight of PEG and entanglement networks. Regarding morphological properties, glycerol-rich blends showed cohesively rough fractures and compatible phases, whereas PEG-rich blends had smooth and noticeable phase separations. For water solubility, pregelatinized starch film dissolved faster than PVA film. PVA/P-St with glycerol-rich film prolonged water-soluble time by improving phase compatibility, whereas the one with PEG-rich film increased solubility. It was worth nothing that elevated temperatures increased solubility in all samples.</p>