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<p>Wound healing is a complex and ongoing phenomenon influenced by various factors, necessitating a conducive environment to expedite the healing process. Effective wound dressings should exhibit biocompatibility and antibacterial properties. In this investigation, a composite film was formulated and utilized as a wound dressing. The film was produced by combining polycaprolactone (PCL), chitosan (CH), and silver ion-exchanged zeolite (Ag-Z) at different concentrations, along with zeolite (Z). The results showed that the incorporation of zeolite not only increased surface roughness but also enhanced the water absorption capacity, which is crucial for the ability to absorb wound secretions. Composite films developed in this research possessed better water uptake abilities, significant antibacterial activity against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>, and an acceptable cell viability rate of over 85%. Interestingly, incorporation of silver-loading zeolite not only improved adhesion of cells but also facilitated better mechanical load-bearing capacity, as confirmed by increased tensile strength and modulus of elasticity. These observations indicate that the developed composite wound dressing possesses the potential to serve as a highly effective choice for facilitating wound healing.</p>

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Synthesis and characterization of novel polycaprolactone/chitosan/Ag-exchange zeolite hydrogel as a wound dressing

  • 期刊论文

  • 发表日期：

    2025年6月25日

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  • Nikoo Sarrafan,
  • S. A. Hassanzadeh-Tabrizi,
  • Narjes Koupaei

摘要

Wound healing is a complex and ongoing phenomenon influenced by various factors, necessitating a conducive environment to expedite the healing process. Effective wound dressings should exhibit biocompatibility and antibacterial properties. In this investigation, a composite film was formulated and utilized as a wound dressing. The film was produced by combining polycaprolactone (PCL), chitosan (CH), and silver ion-exchanged zeolite (Ag-Z) at different concentrations, along with zeolite (Z). The results showed that the incorporation of zeolite not only increased surface roughness but also enhanced the water absorption capacity, which is crucial for the ability to absorb wound secretions. Composite films developed in this research possessed better water uptake abilities, significant antibacterial activity against Escherichia coli and Staphylococcus aureus, and an acceptable cell viability rate of over 85%. Interestingly, incorporation of silver-loading zeolite not only improved adhesion of cells but also facilitated better mechanical load-bearing capacity, as confirmed by increased tensile strength and modulus of elasticity. These observations indicate that the developed composite wound dressing possesses the potential to serve as a highly effective choice for facilitating wound healing.