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<p>In this research, we successfully synthesized an injectable, self-healing hydrogel based on succinyl chitosan (SC)/oxidized pectin (OP)/cellulose nanofibers (CNFs). This hydrogel was formed via the cooperative interaction of imine bonds, and hydrogen bonding, eliminating the necessity for a cross-linking agent. In all cases, the gelation occurred within seconds (&lt; 60&#xa0;s). The hydrogels demonstrated regeneration within a duration of 16&#xa0;min, as determined by visual and rheological evaluations, without the need for any supplementary external stimuli. The elastic modulus of the SC/OP/CNF hydrogels was greater than that of the SC/OP hydrogel produced without CNF. Furthermore, SC/OP/CNF hydrogel showed excellent compatibility with blood (hemolysis rate &lt; 3). Cytotoxicity studies, including MTT, and DAPI staining of hydrogels using human fibroblast cells (HFFF2) validated their good cytocompatibility. The results indicated that the prepared hydrogels could be used as injectable, self-healing hydrogel in biomedical contexts.</p>

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Synthesis and characterization of an injectable, self-healing hydrogel based on succinyl chitosan, oxidized pectin, and cellulose nanofiber for biomedical applications

  • 期刊论文

  • 发表日期：

    2025年2月12日

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  • Atefeh Afroozan Bazghaleh,
  • Mojtaba Akbari Dogolsar,
  • Roya Salehi,
  • Jalal Barzin

摘要

In this research, we successfully synthesized an injectable, self-healing hydrogel based on succinyl chitosan (SC)/oxidized pectin (OP)/cellulose nanofibers (CNFs). This hydrogel was formed via the cooperative interaction of imine bonds, and hydrogen bonding, eliminating the necessity for a cross-linking agent. In all cases, the gelation occurred within seconds (< 60 s). The hydrogels demonstrated regeneration within a duration of 16 min, as determined by visual and rheological evaluations, without the need for any supplementary external stimuli. The elastic modulus of the SC/OP/CNF hydrogels was greater than that of the SC/OP hydrogel produced without CNF. Furthermore, SC/OP/CNF hydrogel showed excellent compatibility with blood (hemolysis rate < 3). Cytotoxicity studies, including MTT, and DAPI staining of hydrogels using human fibroblast cells (HFFF2) validated their good cytocompatibility. The results indicated that the prepared hydrogels could be used as injectable, self-healing hydrogel in biomedical contexts.