<p>We study S=1/2 quantum spin chains with shift-invariant and inversion-symmetric next-nearest-neighbor interaction, also known as zigzag spin chains. We completely classify the integrability and non-integrability of the above class of spin systems. We prove that in this class there are only two integrable models, a classical model and a model solvable by the Bethe ansatz, and all the remaining systems are non-integrable. Our classification theorem confirms that within this class of spin chains, there is no missing integrable model. This theorem also implies the absence of intermediate models with a finite number of local conserved quantities.</p>