<p>The solubility of calcium gluconate in binary solvent systems of (water + 1-propanol) and (water + 2-propanol) was investigated over a temperature range of 298.2 to 313.2&#xa0;K. Measurements were conducted using a laser-based robotic system, and the results show that calcium gluconate is more soluble in water-rich mixtures, and its solubility increased with temperature. To model these data, several thermodynamic and activity-based equations were used. All models proved highly accurate in predicting solubility, confirming their reliability for similar solvents. Thermodynamic properties of dissolution, namely, the standard Gibbs free energy (Δ<i>G°</i>), enthalpy (Δ<i>H°</i>), and entropy (Δ<i>S°</i>), were calculated from the van't Hoff and Gibbs equations. Thermodynamic analysis showed the standard state&#xa0;dissolution process was endothermic (absorbing heat) and non-spontaneous (requiring energy input), as indicated by positive Δ<i>H</i>^<i>0</i> and Δ<i>G</i>^<i>0</i> values.</p>