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<p>The main objective of this research was to analyze the equilibrium solubility of sodium sulfamerazine (NaSMR) in several {ethanol (EtOH, 1) + water (2)} mixtures as reported in the practical concentration scales of mass/volume and mass/mass percentages at different temperatures from 5.0 to 35.0&#xa0;°C. It is observed that aqueous-alcoholic solubility of sodium sulfamerazine increases almost linearly with temperature-increasing, but it decreases non-linearly with EtOH proportion increasing in the mixtures. Logarithmic mass/volume % solubility was adequately correlated by using a bivariate model involving temperature (in °C) and mixtures’ composition expressed in mass fraction of ethanol as independent variables. These NaSMR solubility values were also well correlated with some Jouyban–Acree-based models. Moreover, an adapted version of the Jouyban–Acree model was used to represent the density of the NaSMR-saturated {ethanol (1) + water (2)} mixtures at different temperatures and mixtures compositions. Furthermore, the apparent specific volumes of NaSMR at saturation were also calculated in all the systems from the densities of saturated solutions and cosolvent mixtures free of NaSMR and the composition of every mixture. These findings provide valuable insights into the equilibrium solubility and volumetric contribution of NaSMR, which could be useful for optimization of pharmaceutical formulation and drug purification processes.</p>

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Solubility and Apparent Specific Volume of Sodium Sulfamerazine in Aqueous-Ethanolic Mixtures

  • 期刊论文

  • 发表日期：

    2026年1月19日

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  • Daniel R. Delgado,
  • Fleming Martinez,
  • M. Ángeles Peña,
  • Abolghasem Jouyban,
  • William E. Acree Jr.

摘要

The main objective of this research was to analyze the equilibrium solubility of sodium sulfamerazine (NaSMR) in several {ethanol (EtOH, 1) + water (2)} mixtures as reported in the practical concentration scales of mass/volume and mass/mass percentages at different temperatures from 5.0 to 35.0 °C. It is observed that aqueous-alcoholic solubility of sodium sulfamerazine increases almost linearly with temperature-increasing, but it decreases non-linearly with EtOH proportion increasing in the mixtures. Logarithmic mass/volume % solubility was adequately correlated by using a bivariate model involving temperature (in °C) and mixtures’ composition expressed in mass fraction of ethanol as independent variables. These NaSMR solubility values were also well correlated with some Jouyban–Acree-based models. Moreover, an adapted version of the Jouyban–Acree model was used to represent the density of the NaSMR-saturated {ethanol (1) + water (2)} mixtures at different temperatures and mixtures compositions. Furthermore, the apparent specific volumes of NaSMR at saturation were also calculated in all the systems from the densities of saturated solutions and cosolvent mixtures free of NaSMR and the composition of every mixture. These findings provide valuable insights into the equilibrium solubility and volumetric contribution of NaSMR, which could be useful for optimization of pharmaceutical formulation and drug purification processes.