<p>1,2-difluoro-4,5-dinitrobenzene (DFDNB), as a new type of insensitive fused explosive carrier, has the advantages of high energy density, good thermal stability, and low mechanical sensitivity. Its purity directly affects the use of the product. However, there is still a lack of systematic research on the solubility of DFDNB, which seriously restricts the development and optimization of its purification process. In response to this issue, this study used the laser dynamic method to determine the solubility of DFDNB in a methanol + water binary mixed solvent system within the temperature range of 279.15 ~ 333.15&#xa0;K and constructed a complete solubility curve. At the same time, Hansen solubility parameters were used to quantitatively analyze the solubility of DFDNB in the binary system. To enhance the theoretical guidance value of the data, the Apelblat equation, Yaws model, Van’t Hoff equation, General Cosolvency model, and Jouyban–Acree model were used to correlate and predict the experimental data. The goodness of fit (<i>R</i>² &gt; 0.99) of all models showed good applicability. This study not only fills the gap in solubility data of DFDNB, but also provides a key theoretical basis for the optimization of its crystallization purification process, such as solvent ratio screening and temperature control strategy.</p>