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<p>The interactions of pyrimethamine (PMA) with DNA, RNA, BSA, dendrimer, α-cyclodextrin (α-CD), β-cyclodextrin (β-CD), various solvents, silver nanoparticles, and silver/cobalt nanoparticles were investigated. The doping effects of PMA/CD complexes with Ag and Ag/Co were characterized using UV–vis, fluorescence, FTIR, FE-SEM, TEM, XRD, and DSC techniques. Nanoparticle sizes were determined through TEM-EDS and XRD analysis. The inclusion behavior and thermodynamic parameters of the PMA/CD inclusion complexes were evaluated using the PM3 computational method. The antibacterial and anticancer properties of the nanomaterials and PMA drug were also assessed. Compared to the PMA, PMA/CD, and PMA/biomolecules, red or blue shifted absorption and fluorescence maxima were noticed in Ag/PM/CD, Ag/Co/PM/CD, and Ag/PM/biomolecule nanoparticles. TEM imaging confirmed the formation of nanocrystals in Ag/PMA/β-CD and Ag/Co/PMA/β-CD systems. The isolated PMA, Ag/PMA/β-CD, and Ag/Co/PMA/β-CD nanomaterials demonstrated notable antibacterial activity, while the PMA drug exhibited anticancer activity against 1r51 and 2oh4 protein targets.</p>

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Spectral, Microscopic, Antibacterial, and Anticancer Activity of Pyrimethamine Drug With Ag Nanoparticles, DNA, RNA, BSA, Dendrimer, and Cyclodextrins

  • 期刊论文

  • 发表日期：

    2025年11月5日

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  • N. Rajendiran,
  • A. Mani,
  • M. Venkatesan,
  • B. Sneha,
  • E. Nivetha,
  • P. Senthilraja

摘要

The interactions of pyrimethamine (PMA) with DNA, RNA, BSA, dendrimer, α-cyclodextrin (α-CD), β-cyclodextrin (β-CD), various solvents, silver nanoparticles, and silver/cobalt nanoparticles were investigated. The doping effects of PMA/CD complexes with Ag and Ag/Co were characterized using UV–vis, fluorescence, FTIR, FE-SEM, TEM, XRD, and DSC techniques. Nanoparticle sizes were determined through TEM-EDS and XRD analysis. The inclusion behavior and thermodynamic parameters of the PMA/CD inclusion complexes were evaluated using the PM3 computational method. The antibacterial and anticancer properties of the nanomaterials and PMA drug were also assessed. Compared to the PMA, PMA/CD, and PMA/biomolecules, red or blue shifted absorption and fluorescence maxima were noticed in Ag/PM/CD, Ag/Co/PM/CD, and Ag/PM/biomolecule nanoparticles. TEM imaging confirmed the formation of nanocrystals in Ag/PMA/β-CD and Ag/Co/PMA/β-CD systems. The isolated PMA, Ag/PMA/β-CD, and Ag/Co/PMA/β-CD nanomaterials demonstrated notable antibacterial activity, while the PMA drug exhibited anticancer activity against 1r51 and 2oh4 protein targets.