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<p>Through liquid-assisted grinding, this study seeks to improve the physicochemical characteristics of medications by employing the eutectic mixture creation technique. The active pharmaceutical ingredient (API) under investigation is celecoxib (CXB), which is a selective cyclooxygenase-2 (COX-2) inhibitor with anti-inflammatory, analgesic, and antipyretic properties, combined with paracetamol over the entire molar fraction range. DSC analysis was used to determine the eutectic point. The solid-phase characterization was performed using X-ray diffraction (XRD), scanning electron microscopy (SEM), and infrared (IR) spectroscopy. The results indicate the formation of a eutectic mixture in a 1:1 stoichiometric ratio, with a melting temperature of 134 °C. XRD and IR analyses confirmed the formation of the eutectic mixture. Scanning electron microscopy (SEM) was employed to analyze morphological differences between the eutectic mixture and its pure components. The creation of a eutectic system with weak molecular interactions in the solid state was demonstrated by the retention of distinctive peaks in PXRD patterns and FT-IR spectra. The interactions and thermodynamic characteristics of the eutectic system were further examined by Density Functional Theory (DFT) computations. The results demonstrated that the eutectic mixture’s physicochemical properties were superior to those of pure CXB. The enhanced stability and viability of the eutectic system were validated by the dipole moment increase and variations in the gaseous phase Gibbs free energy of formation. Moreover, the water solubility of CXB in the eutectic mixture was significantly enhanced compared to the drug taken alone.</p>

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Synthesis, Characterization, Solubility Enhancement and DFT Calculations of Celecoxib/Paracetamol Eutectic Mixture

  • 期刊论文

  • 发表日期：

    2025年10月16日

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  • Messeouda Bouziani,
  • Farida Allal,
  • Omar ElFarouk Houache,
  • Nedjmedine Mellak,
  • Fatima Elzahra Bouziani

摘要

Through liquid-assisted grinding, this study seeks to improve the physicochemical characteristics of medications by employing the eutectic mixture creation technique. The active pharmaceutical ingredient (API) under investigation is celecoxib (CXB), which is a selective cyclooxygenase-2 (COX-2) inhibitor with anti-inflammatory, analgesic, and antipyretic properties, combined with paracetamol over the entire molar fraction range. DSC analysis was used to determine the eutectic point. The solid-phase characterization was performed using X-ray diffraction (XRD), scanning electron microscopy (SEM), and infrared (IR) spectroscopy. The results indicate the formation of a eutectic mixture in a 1:1 stoichiometric ratio, with a melting temperature of 134 °C. XRD and IR analyses confirmed the formation of the eutectic mixture. Scanning electron microscopy (SEM) was employed to analyze morphological differences between the eutectic mixture and its pure components. The creation of a eutectic system with weak molecular interactions in the solid state was demonstrated by the retention of distinctive peaks in PXRD patterns and FT-IR spectra. The interactions and thermodynamic characteristics of the eutectic system were further examined by Density Functional Theory (DFT) computations. The results demonstrated that the eutectic mixture’s physicochemical properties were superior to those of pure CXB. The enhanced stability and viability of the eutectic system were validated by the dipole moment increase and variations in the gaseous phase Gibbs free energy of formation. Moreover, the water solubility of CXB in the eutectic mixture was significantly enhanced compared to the drug taken alone.