<p>Excessive water hardness poses significant challenges to both domestic and industrial water usage, often leading to scale formation and reduced efficiency of water systems. In this article, the removal of total hardness using homogeneous Fenton-activated microcrystalline cellulose (MCC-F) extracted from banana pseudo-stem was investigated. To begin with, FTIR, SEM–EDS, XRD, TGA, and pH_pzc of the prepared material were examined to determine its characterization. Next, a preliminary experiment was conducted to assess the adsorption capacity and reduction percentage of target pollutants from a synthetic solution using MCC-F as an adsorbent. Besides, the Freundlich and Dubinin-Radushkovich isotherms demonstrated excellent correlation with the experimental data (R^<i>2</i> &gt; 0.99), while the pseudo-second-order kinetic model effectively described the adsorption kinetics. Furthermore, the adsorptive elimination of hardness was found to be an exothermic and spontaneous process, as indicated by thermodynamic studies. This study proposes a straightforward setup that addresses the limitations of conventional methods for removing total hardness.</p>