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<p>The aim of this work is to experimentally determine co-solvent effects on the solubility of a poorly water-soluble flavonoid. Naringin, a flavonoid glycoside, was studied as a model poorly water-soluble compound. Two surfactants (sodium lauryl sulfate and polyoxyethylene sorbitan monooleate (Tween 80)), and three cyclodextrins (CDs: β-CD, 2-hydroxypropyl-β-CD, and dimethyl-β-CD) were studied as co-solvents by measuring the solubilities of naringin at 298.15&#xa0;K using high-performance liquid chromatography in water/co-solvent mixtures. The stability constants of the co-solvent/solute systems were evaluated by the Higuchi–Connors solubility method. According to these results, dimethyl-β-CD had the highest co-solvent effect among the CDs. Modeling of the experimental solubility data were performed using the modified Chrastil model.</p>

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Determination of the Effects of Surfactants and Cyclodextrins as Co-solvent on the Solubility of Poorly Water-Soluble Flavonoid Naringin

  • 期刊论文

  • 发表日期：

    2025年3月6日

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  • Hiroyuki Matsuda,
  • Masahiro Kosuge,
  • Rena Yoshimura,
  • Yuma Naito,
  • Tomoya Tsuji,
  • Kiyofumi Kurihara,
  • Katsumi Tochigi

摘要

The aim of this work is to experimentally determine co-solvent effects on the solubility of a poorly water-soluble flavonoid. Naringin, a flavonoid glycoside, was studied as a model poorly water-soluble compound. Two surfactants (sodium lauryl sulfate and polyoxyethylene sorbitan monooleate (Tween 80)), and three cyclodextrins (CDs: β-CD, 2-hydroxypropyl-β-CD, and dimethyl-β-CD) were studied as co-solvents by measuring the solubilities of naringin at 298.15 K using high-performance liquid chromatography in water/co-solvent mixtures. The stability constants of the co-solvent/solute systems were evaluated by the Higuchi–Connors solubility method. According to these results, dimethyl-β-CD had the highest co-solvent effect among the CDs. Modeling of the experimental solubility data were performed using the modified Chrastil model.