<p>Experimental molar solubility data for sodium acetate trihydrate (NaAc·3H₂O) dissolved in binary solvent mixtures of methanol, ethanol, 1-propanol, acetonitrile, and water at 298.2&#xa0;K was determined using the shake–flask equilibration method followed by the quantification of the dissolved solute by flame photometric determination. Differential scanning calorimetry (DSC) analyses of both the un-processed and equilibrated NaAc·3H₂O in the neat solvents were recorded at 298.2&#xa0;K to determine the thermal behavior of NaAc·3H₂O. The experimental solubility data were analyzed using a linear model of Jouyban-Acree. The applicability of the model to describe the observed solubility data was assessed by calculating the mean percentage deviations between the back-calculated and experimental values. Also, the combined nearly ideal binary solvent/Redlich–Kister (CNIBS/R-K) equation was employed to provide a mathetically description the solubility data under isothermal conditions. The possibility of prediction of the solubility of trihydrate form of sodium acetate based on the CNIBS/R-K model trained using the experimental solubility of the anhydrous form was also investigated. The computational results indicated that the models considered yielded solubility predictions within an acceptable error level.</p>