<p>This study adopted a cross-sectional moderation analysis to examine whether religious attendance buffers the negative effects of role overload on caregivers’ health. A total of 1455 family caregivers of older persons (mean age = 63.05&#xa0;years; 67.4% female) drawn from the National Study of Caregiving (NSOC IV) in the United States in 2021 constituted the sample and were measured by the three-item Role Overload Scale, a single-item self-rated health measure, the four-item Patient Health Questionnaire (PHQ-4), and a six-item physical health scale. Caregivers, on average, reported moderate to high ratings of self-rated health (M = 3.43, SD = 1.03), mental health (M = 13.99, SD = 2.39), and physical health (M = 25.18, SD = 4.55). Additionally, 54% of caregivers had attended religious services in the past month. Regression analyses demonstrated that role overload was a significant negative predictor of self-rated health (B = – 0.188, <i>p &lt; </i>0.001), mental health (B = – 0.576, <i>p &lt; </i>0.001), and physical health (B = – 1.075, <i>p &lt; </i>0.001). Religious attendance significantly moderated the associations between role overload and self-rated health (B = 0.083, <i>p = </i>0.004) and mental health (B = 0.176, <i>p = </i>0.009), but not physical health (B = 0.213, <i>p = </i>0.097). The findings highlight that religious or spiritual engagement may contribute to buffering the health consequences of caregiving-related stress. Health professionals and religious leaders should consider working collaboratively to promote religious involvement, integrate spiritual support into caregiver services, and develop community-based interventions that address both psychological and physical health needs of family caregivers.</p>