<p>Church leaders balance work, family, and guiding new members, increasing stress and affecting their quality of life. However, key factors influencing their well-being remain unclear. This study examines the impact of perceived stress, resilience, and religious coping on quality of life, controlling for sociodemographic factors. Fifty United Pentecostal Church of Colombia leaders (mean age: 47.34, <i>SD</i> = 6.04) completed an online assessment measuring perceived stress, resilience, religious coping, and quality of life. Results of hierarchical regressions showed that religious coping was a statistically significant independent predictor of better overall quality of life (<i>p</i> = 0.035), alongside lower perceived stress (<i>p</i> = 0.009) and higher resilience (<i>p</i> = 0.02). Together, all predictors included in the model explained 16% of the variance in quality of life. The quality-of-life subscales with the highest percentage of explained variance were physical health status/activities (62%), work (57%), and social relationships (55%), mainly due to higher resilience. Household activities (34%) and mood (20%) were influenced by lower stress and higher resilience. These findings suggest that resilience and religious coping, combined with lower perceived stress, contribute to a better quality of life in church leaders, highlighting the need for targeted interventions.</p>