<p>This study aimed to investigate the role of religion and spirituality (R/S) in sports-related injuries through a systematic review. The review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement and encompassed 14 studies that met the specified criteria. The selected studies were categorized into four primary areas: (1) the potential positive impact of R/S on the prevention of sports-related injuries, (2) R/S as a spiritual need during the treatment and rehabilitation of sports injuries, (3) the role of R/S as an effective coping strategy following sports injuries, and (4) the potential negative impact of Ramadan on the incidence of sports injuries. The findings of this study highlight that R/S plays at various stages of sports injuries, particularly for athletes with religious affiliations. Further research should delve deeper into specific psychological interventions based on R/S to contribute to preventing, treating, and rehabilitating sports injuries.</p>